Certificate of Analysis
Each batch of Semax undergoes rigorous third-party testing to ensure purity and identity verification. View the full lab report below.
Semax
Semax is a synthetic heptapeptide derived from the ACTH (4-10) fragment. This research-grade peptide is extensively studied for its nootropic and neuroprotective properties, as well as its effects on BDNF/NGF expression and neurotrophin signaling in laboratory settings.
99%+
10mg
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For Research Use Only
Intended for in-vitro research only. Not for human consumption. Must be 21+.
Specifications
Certificate of Analysis
Each batch of Semax undergoes rigorous third-party testing to ensure purity and identity verification. View the full lab report below.
Research background
Selank and Semax: Neurotrophic Peptide Research
Two short Pro-Gly-Pro-stabilized peptides from the Russian Academy of Sciences: what the rat, in vitro and clinical studies of Semax and Selank actually report, where the evidence is thin, and how to handle the material in the lab.
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This compound is part of a curated set. Same vials, same testing, lower total.
Overview
Biochemical Characteristics
Semax is a synthetic derivative of ACTH (4-10), which represents the core fragment responsible for the neurotropic effects of ACTH. The addition of Pro-Gly-Pro enhances metabolic stability and extends the half-life in experimental models.
Research Applications
Pathway / Mechanistic Context
Preclinical Research Summary
Form & Analytical Testing
Mechanisms of Action
BDNF/NGF Expression - Upregulates brain-derived neurotrophic factor and nerve growth factor
Dopamine/Serotonin Modulation - Influences catecholamine and serotonin system activity
TrkB Receptor Activation - Stimulates tropomyosin receptor kinase B signaling pathways
Neuroprotection - Reduces oxidative stress and supports neuronal survival under stress conditions
Research Applications
1Cognitive Enhancement Research
Semax is primarily studied for its effects on learning, memory, and attention.
Key Research Findings
- Enhances memory consolidation and retrieval in research models
- Improves attention and cognitive flexibility in behavioral paradigms
- Increases BDNF expression in hippocampus and cortex
- Supports synaptic plasticity through neurotrophin signaling
2Neuroprotection Research
Research explores effects on neuronal survival under stress conditions.
Key Research Findings
- Reduces neuronal damage in ischemia-reperfusion models
- Decreases oxidative stress markers in neural tissue
- Promotes NGF and BDNF-mediated neuroprotection
- Modulates inflammatory cytokines in brain injury models
3Neurotrophin Signaling Research
Studies investigate effects on growth factor expression and signaling.
Key Research Findings
- Upregulates BDNF and NGF gene expression
- Activates TrkB receptor signaling pathways
- Enhances neurite outgrowth in cultured neurons
- Modulates transcription factors related to neuroplasticity
Supporting Research & Bibliography
The following peer-reviewed publications support the research applications described above. References are provided for informational purposes to assist researchers in their literature review.
Effectiveness of semax in acute period of hemispheric ischemic stroke
Gusev EI, Skvortsova VI, Miasoedov NF, et al.
Total references: 2
Note: The information provided is for research reference only. It summarizes published in-vitro, animal and, where cited, human clinical studies of the compound; findings from those studies are not claims about this product. This product is intended for laboratory research purposes only. Not for human or veterinary use.
Research Use Only: This product is intended for laboratory research purposes only. Not for human or veterinary use. By purchasing, you confirm that you are a qualified researcher and will use this product in accordance with all applicable regulations.