Certificate of Analysis
Each batch of Epithalon undergoes rigorous third-party testing to ensure purity and identity verification. The lab report for the latest batch is being finalized.
Epithalon
Epithalon (Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. This research compound has been studied for its potential effects on telomerase activation in laboratory settings.
99%+
50mg
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For Research Use Only
Intended for in-vitro research only. Not for human consumption. Must be 21+.
Specifications
Certificate of Analysis
Each batch of Epithalon undergoes rigorous third-party testing to ensure purity and identity verification. The lab report for the latest batch is being finalized.
Research background
Epithalon: Telomerase Activation and Longevity Research
What the Epithalon (AEDG) literature actually shows about telomerase, telomere length, melatonin and lifespan, in which models, and why most of it comes from a single research group.
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Overview
Biochemical Characteristics
Epithalon is a short-chain tetrapeptide representing the active core of the larger Epithalamin polypeptide complex. Its minimal structure enables efficient cellular uptake and nuclear translocation, where it interacts with telomerase regulatory elements in experimental models.
Research Applications
Pathway / Mechanistic Context
Preclinical Research Summary
Form & Analytical Testing
Mechanisms of Action
Telomerase Activation - Stimulates hTERT gene expression and telomerase enzyme activity
Pineal Gland Regulation - Normalizes melatonin synthesis and circadian rhythm patterns
Antioxidant Enhancement - Upregulates superoxide dismutase and glutathione peroxidase
Gene Expression Modulation - Affects age-related transcriptional programs
Research Applications
1Telomere & Cellular Aging Research
Epithalon is primarily studied for its effects on telomere biology and cellular senescence.
Key Research Findings
- Increases telomerase activity in somatic cells
- Extends telomere length in cultured fibroblasts
- Reduces markers of cellular senescence
- Improves cell proliferation capacity in aged cells
2Neuroendocrine Function
Research explores effects on pineal gland and hormonal regulation.
Key Research Findings
- Normalizes circadian rhythm patterns in aged animal models
- Restores melatonin secretion in aged animal models
- Modulates cortisol and other stress hormones
- Improves sleep architecture in research models
3Antioxidant & Protective Effects
Studies indicate enhanced cellular protection mechanisms.
Key Research Findings
- Increases superoxide dismutase activity
- Enhances glutathione peroxidase levels
- Reduces lipid peroxidation markers
- Protects against oxidative DNA damage
Supporting Research & Bibliography
The following peer-reviewed publications support the research applications described above. References are provided for informational purposes to assist researchers in their literature review.
Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice
Kossoy G, Anisimov VN, Ben-Hur H, et al.
Total references: 3
Note: The information provided is for research reference only. It summarizes published in-vitro, animal and, where cited, human clinical studies of the compound; findings from those studies are not claims about this product. This product is intended for laboratory research purposes only. Not for human or veterinary use.
Research Use Only: This product is intended for laboratory research purposes only. Not for human or veterinary use. By purchasing, you confirm that you are a qualified researcher and will use this product in accordance with all applicable regulations.