Certificate of Analysis
Each batch of PT-141 undergoes rigorous third-party testing to ensure purity and identity verification. View the full lab report below.
PT-141 (Bremelanotide)
99%+ purity, independently tested · View COA
Ships same day when ordered before 2 PM EST · tracked and discreet
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide melanocortin receptor agonist derived from Melanotan II. This research-grade peptide acts at melanocortin receptors and is studied chiefly for its MC4R activity and is extensively studied for its effects on central nervous system melanocortin signaling pathways in laboratory settings.
99%+
10mg
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Order before 2 PM EST, ships the same day. Fast, fully tracked, and sent in discreet, secure packaging. Free shipping on orders over $99.
Purity Guarantee. If independent third-party testing doesn't confirm our stated purity standards, you get a full refund plus a free replacement.
For Research Use Only
Intended for in-vitro research only. Not for human consumption. Must be 21+.
Specifications
Certificate of Analysis
Each batch of PT-141 undergoes rigorous third-party testing to ensure purity and identity verification. View the full lab report below.
Research background
PT-141 (Bremelanotide): Melanocortin System Research
PT-141 (bremelanotide) is a cyclic melanocortin agonist descended from Melanotan II. This guide covers its structure, receptor profile, the rat, primate and human studies behind it, how it differs from the approved drug Vyleesi, and how to study and handle it in the lab.
Overview
Biochemical Characteristics
PT-141 is a cyclic lactam peptide featuring a ring structure formed by an amide bond between aspartic acid and lysine side chains. The free carboxylic acid C-terminus distinguishes it from Melanotan II, contributing to its distinct receptor binding profile in experimental models.
Research Applications
Pathway / Mechanistic Context
Preclinical Research Summary
Form & Analytical Testing
Mechanisms of Action
MC3R/MC4R Agonism - Selective activation of melanocortin-3 and melanocortin-4 receptors in the CNS
Central Nervous System Action - Acts primarily through hypothalamic melanocortin pathways
Dopaminergic Modulation - Influences dopamine release in mesolimbic reward circuits
Melanocortin Receptor Profile - A nonselective melanocortin agonist studied chiefly for its MC4R activity; it differs from Melanotan II by a free-acid C-terminus
Research Applications
1Melanocortin Receptor Research
PT-141 is primarily studied for its selective effects on central melanocortin receptors.
Key Research Findings
- Agonist at multiple melanocortin receptors, studied chiefly at MC4R
- C-terminal free acid in place of Melanotan II's amide
- Acts primarily through central nervous system pathways
- Useful tool for studying hypothalamic melanocortin circuits
2Central Nervous System Pharmacology
Research explores PT-141's effects on CNS signaling and neuronal activation.
Key Research Findings
- Activates hypothalamic melanocortin pathways
- Modulates dopaminergic signaling in research models
- Crosses blood-brain barrier effectively
- Enables structure-activity relationship studies
3Comparative Melanocortin Studies
Studies compare PT-141 to other melanocortin agonists.
Key Research Findings
- Distinct receptor selectivity profile vs. Melanotan II
- Different peripheral vs. central effect balance
- Valuable for understanding melanocortin receptor subtypes
- Enables comparative pharmacology research
Supporting Research & Bibliography
The following peer-reviewed publications support the research applications described above. References are provided for informational purposes to assist researchers in their literature review.
Total references: 4
Note: The information provided is for research reference only. It summarizes published in-vitro, animal and, where cited, human clinical studies of the compound; findings from those studies are not claims about this product. This product is intended for laboratory research purposes only. Not for human or veterinary use.
Common questions
- What purity is PT-141, and how is it tested?
- PT-141 is supplied at 99%+ purity. Each production lot is tested by an independent third-party laboratory, with HPLC for purity and mass spectrometry for identity. Published certificates can be looked up by the lot number printed on your vial in our COA library.
- Does PT-141 come with a Certificate of Analysis?
- Certificates are published online rather than printed in the box. You can view and download the certificate on this page before you buy, and match the lot number on your vial to its certificate in the COA library. Our guide on how to read a peptide COA explains each section.
- How fast does PT-141 ship?
- Orders placed before 2 PM EST ship the same day from the United States, with tracking and discreet packaging.
- How should PT-141 be stored?
- Store at -20°C. Our storage and handling guide covers temperature, light and moisture in more detail.
- What if independent testing doesn't confirm the stated purity?
- Our Purity Guarantee covers it: if independent testing does not confirm the stated purity, you get a full refund and a free replacement.
- Is PT-141 for human use?
- No. PT-141 is sold strictly for laboratory research use only. It is not for human or veterinary use, and we do not provide dosing or administration guidance.
Research Use Only: This product is intended for laboratory research purposes only. Not for human or veterinary use. By purchasing, you confirm that you are a qualified researcher and will use this product in accordance with all applicable regulations.