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MOTS-c
Specialty Peptides

MOTS-c

$89.99In Stock

MOTS-c is a mitochondrial-derived peptide consisting of 16 amino acids. This research compound is studied for its role in metabolic regulation and cellular energy pathways.

Purity

99%+

Size

10mg

1
COA Available
Lab Verified
Fast Shipping

Specifications

Molecular Weight2,174.45 Da
Sequence16 Amino Acids
AppearanceWhite lyophilized powder
StorageStore at -20°C
SolubilitySoluble in sterile water

Certificate of Analysis

Each batch of MOTS-c undergoes rigorous third-party testing to ensure purity and identity verification. COA documentation is available upon request.

HPLC Purity Analysis
Mass Spectrometry Verification
Lot-Specific Documentation

Extended Research Applications & Mechanisms

Scientific Profile

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial genome. It is a key regulator of metabolic homeostasis and represents a novel class of mitochondrial-derived peptides.

Mechanisms of Action

1

AMPK Activation - Activates cellular energy sensor

2

Metabolic Regulation - Enhances glucose utilization

3

Mitochondrial Function - Improves mitochondrial efficiency

4

Insulin Sensitization - Enhances insulin signaling

Research Applications

1Metabolic & Diabetes Research

Primary research focus on metabolic regulation.

Key Research Findings
  • Improves insulin sensitivity significantly
  • Enhances glucose uptake in muscle tissue
  • Reduces diet-induced obesity in models
  • Prevents metabolic dysfunction

2Exercise & Muscle Biology

Studies on exercise mimetics and muscle function.

Key Research Findings
  • Mimics certain exercise-induced benefits
  • Improves physical endurance in models
  • Enhances mitochondrial biogenesis
  • Activates exercise-responsive genes

3Aging & Longevity Research

Studies on age-related metabolic decline.

Key Research Findings
  • Levels decline with age naturally
  • Restores metabolic function in aged models
  • May extend healthspan in research
  • Protects against age-related diseases

Supporting Research & Bibliography

The following peer-reviewed publications support the research applications described above. References are provided for informational purposes to assist researchers in their literature review.

1

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Lee C, Zeng J, Drew BG, et al.

Cell Metabolism2015;21:443-454DOIPubMed
2

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

Reynolds JC, Lai RW, Woodhead JST, et al.

Nature Communications2021;12:470DOIPubMed
3

The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression

Kim KH, Son JM, Benayoun BA, Lee C.

Cell Metabolism2018;28:516-524DOIPubMed

Total references: 3

Note: The information provided is for research reference only. All research applications are based on in-vitro and animal studies. This product is intended for laboratory research purposes only. Not for human or veterinary use.

Research Use Only: This product is intended for laboratory research purposes only. Not for human or veterinary use. By purchasing, you confirm that you are a qualified researcher and will use this product in accordance with all applicable regulations.