Certificate of Analysis
Each batch of IGF-1 LR3 undergoes rigorous third-party testing to ensure purity and identity verification. View the full lab report below.
IGF-1 LR3
Long R3 Insulin-like Growth Factor-1 is an 83 amino acid analog of IGF-1. The LR3 modification provides enhanced stability and potency for research applications.
99%+
1mg
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For Research Use Only
Intended for in-vitro research only. Not for human consumption. Must be 21+.
Specifications
Certificate of Analysis
Each batch of IGF-1 LR3 undergoes rigorous third-party testing to ensure purity and identity verification. View the full lab report below.
Research background
IGF-1 LR3: Long-Acting Growth Factor Research
IGF-1 LR3 is an 83-residue IGF-I analog built to escape IGF-binding proteins. This guide covers how that design produces its potency, what the cell and rat studies show, what is actually known about its persistence, and how to test and handle it.
Overview
Biochemical Characteristics
IGF-1 LR3 contains a 13-amino acid extension at the N-terminus and an arginine-for-glutamic acid substitution at position 3. These modifications markedly reduce binding to IGF binding proteins while retaining IGF-1 receptor activity; in cell systems that secrete binding proteins this makes it more potent than native IGF-1, while in systems without them it can be less potent.
Research Applications
Pathway / Mechanistic Context
Preclinical Research Summary
Form & Analytical Testing
Mechanisms of Action
IGF-1 Receptor Activation - High-affinity binding to IGF-1R with full agonist activity
IGFBP Resistance - Markedly reduced binding to IGF binding proteins compared with native IGF-1
PI3K/Akt Signaling - Activates phosphoinositide 3-kinase and downstream Akt pathway for cell survival
Extended Half-Life - Prolonged biological activity due to reduced IGFBP sequestration and clearance
Research Applications
1Muscle Biology Research
Studies on muscle growth, protein synthesis, and regeneration.
Key Research Findings
- Potent stimulator of muscle protein synthesis via mTORC1 activation
- Promotes satellite cell activation and myoblast proliferation
- Enhances muscle fiber hypertrophy in research models
- Supports muscle regeneration and repair pathway studies
2Cell Proliferation & Survival Studies
Research on growth factor signaling and cell biology.
Key Research Findings
- Activates IGF-1R with full agonist efficacy
- Promotes cell survival through PI3K/Akt pathway
- Stimulates cell division through MAPK signaling
- Extended half-life enables sustained receptor activation
3IGFBP-Independent Signaling Studies
Investigation of direct IGF-1R effects without IGFBP modulation.
Key Research Findings
- Markedly reduced IGFBP binding affinity compared with native IGF-1
- Enables study of direct IGF-1R-mediated effects
- Prolonged bioavailability compared to native IGF-1
- Useful for structure-activity relationship studies
Supporting Research & Bibliography
The following peer-reviewed publications support the research applications described above. References are provided for informational purposes to assist researchers in their literature review.
Total references: 4
Note: The information provided is for research reference only. It summarizes published in-vitro, animal and, where cited, human clinical studies of the compound; findings from those studies are not claims about this product. This product is intended for laboratory research purposes only. Not for human or veterinary use.
Research Use Only: This product is intended for laboratory research purposes only. Not for human or veterinary use. By purchasing, you confirm that you are a qualified researcher and will use this product in accordance with all applicable regulations.