IGF-1 LR3
Long R3 Insulin-like Growth Factor-1 is an 83 amino acid analog of IGF-1. The LR3 modification provides enhanced stability and potency for research applications.
99%+
0.1mg
Specifications
Extended Research Applications & Mechanisms
Scientific Profile
IGF-1 LR3 (Long R3 IGF-1) is an 83-amino acid analog of human IGF-1 with modifications that prevent binding to IGF binding proteins. This results in enhanced potency and extended half-life compared to native IGF-1.
Mechanisms of Action
IGF-1 Receptor Activation - Direct receptor binding
Reduced IGFBP Binding - Enhanced bioavailability
Anabolic Signaling - Activates PI3K/Akt pathway
Extended Half-Life - Prolonged biological activity
Research Applications
1Muscle Biology Research
Studies on muscle growth and regeneration.
Key Research Findings
- Potent stimulator of muscle protein synthesis
- Promotes satellite cell activation
- Enhances muscle fiber hypertrophy
- Supports muscle regeneration research
2Cell Culture Applications
Widely used in in vitro research settings.
Key Research Findings
- Superior to native IGF-1 in cell culture
- Supports cell proliferation studies
- Used in stem cell maintenance
- Essential for serum-free media formulations
3Metabolic Research
Studies on glucose and lipid metabolism.
Key Research Findings
- Enhances glucose uptake in muscle cells
- Promotes glycogen synthesis
- Reduces protein catabolism
- Modulates lipid metabolism
Supporting Research & Bibliography
The following peer-reviewed publications support the research applications described above. References are provided for informational purposes to assist researchers in their literature review.
Type I insulin-like growth factor receptor signaling in skeletal muscle regeneration and hypertrophy
Philippou A, Halapas A, Maridaki M, Koutsilieris M.
Total references: 3
Note: The information provided is for research reference only. All research applications are based on in-vitro and animal studies. This product is intended for laboratory research purposes only. Not for human or veterinary use.
Research Use Only: This product is intended for laboratory research purposes only. Not for human or veterinary use. By purchasing, you confirm that you are a qualified researcher and will use this product in accordance with all applicable regulations.
