KPV (Lysine-Proline-Valine)
KPV is a naturally occurring anti-inflammatory tripeptide derived from alpha-melanocyte stimulating hormone (α-MSH). This C-terminal fragment represents the minimal active sequence responsible for α-MSH's potent anti-inflammatory and antimicrobial properties, making it valuable for inflammation and immune research.
99%+
10mg
For Research Use Only (RUO)
This product is intended for in-vitro research applications only. Not for human or animal consumption, cosmetic use, or as a dietary supplement. All customers must be at least 21 years of age. It is the researcher's responsibility to handle materials in accordance with their institution's safety protocols and all applicable laws.
Specifications
Certificate of Analysis
Each batch of KPV undergoes rigorous third-party testing to ensure purity and identity verification. Download your COA instantly.
Extended Research Applications & Mechanisms
Overview
Biochemical Characteristics
Mechanisms of Action
NF-κB Inhibition - Blocks nuclear translocation and DNA binding of NF-κB
Cytokine Modulation - Reduces production of TNF-α, IL-1β, IL-6, and IL-8
Antimicrobial Activity - Direct bactericidal effects through membrane disruption
Receptor-Independent Action - Acts through non-melanocortin receptor pathways
Research Applications
1Inflammation & Immune Research
Primary research focus on anti-inflammatory mechanisms and immune modulation.
Key Research Findings
- Reduces inflammatory cytokine production by 60-80% in cell models
- Inhibits NF-κB activation in multiple cell types
- Decreases neutrophil infiltration in inflammation models
- Modulates macrophage polarization toward anti-inflammatory phenotype
Note: The information provided is for research reference only. All research applications are based on in-vitro and animal studies. This product is intended for laboratory research purposes only. Not for human or veterinary use.
Research Use Only: This product is intended for laboratory research purposes only. Not for human or veterinary use. By purchasing, you confirm that you are a qualified researcher and will use this product in accordance with all applicable regulations.
