Certificate of Analysis
Each batch of KPV undergoes rigorous third-party testing to ensure purity and identity verification. View the full lab report below.
KPV (Lysine-Proline-Valine)
99%+ purity, independently tested · View COA
Ships same day when ordered before 2 PM EST · tracked and discreet
KPV is a naturally occurring anti-inflammatory tripeptide derived from alpha-melanocyte stimulating hormone (α-MSH). This C-terminal fragment represents the minimal active sequence responsible for α-MSH's potent anti-inflammatory and antimicrobial properties, making it valuable for inflammation and immune research.
99%+
10mg
Bundle & Save
Order before 2 PM EST, ships the same day. Fast, fully tracked, and sent in discreet, secure packaging. Free shipping on orders over $99.
Purity Guarantee. If independent third-party testing doesn't confirm our stated purity standards, you get a full refund plus a free replacement.
For Research Use Only
Intended for in-vitro research only. Not for human consumption. Must be 21+.
Specifications
Certificate of Analysis
Each batch of KPV undergoes rigorous third-party testing to ensure purity and identity verification. View the full lab report below.
Research background
KPV: Alpha-MSH Fragment for Inflammation Research
KPV (Lys-Pro-Val) is the C-terminal tripeptide of alpha-MSH. A research guide to how it enters cells through PepT1, how it blocks NF-κB nuclear import, what the colitis and inflammation models showed, the unresolved melanocortin-receptor question, and practical notes for the lab.
Overview
Biochemical Characteristics
KPV corresponds to amino acids 11-13 of α-MSH. Unlike full-length α-MSH, this tripeptide exerts anti-inflammatory effects through melanocortin receptor-independent pathways, enabling studies of direct NF-κB inhibition in experimental models.
Research Applications
Pathway / Mechanistic Context
Preclinical Research Summary
Form & Analytical Testing
Mechanisms of Action
NF-κB Inhibition - Blocks nuclear translocation and DNA binding of NF-κB transcription factors
Cytokine Modulation - Reduces production of pro-inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8
Antimicrobial Activity - Inhibited Staphylococcus aureus and Candida albicans in vitro, with a cAMP-linked mechanism proposed
Receptor-Independent Action - Acts through non-melanocortin receptor pathways unlike parent α-MSH
Research Applications
1Inflammation & Immune Research
Primary research focus on anti-inflammatory mechanisms and immune modulation.
Key Research Findings
- Reduces inflammatory cytokine production in cell models
- Inhibits NF-κB nuclear translocation in multiple cell types
- Decreases neutrophil infiltration in inflammation models
- Investigated for effects on macrophage inflammatory signaling
2Gastrointestinal Research
Studies on intestinal inflammation and mucosal protection.
Key Research Findings
- Reduces inflammation in experimental colitis models
- Protects intestinal epithelial barrier function
- Decreases inflammatory cytokines in gut tissue
- Supports mucosal healing in injury models
3Antimicrobial Research
Investigation of direct antibacterial properties.
Key Research Findings
- Demonstrates bactericidal activity against multiple species
- Disrupts bacterial membrane integrity
- Inhibited Staphylococcus aureus and Candida albicans in vitro
- Potential dual anti-inflammatory and antimicrobial effects
Supporting Research & Bibliography
The following peer-reviewed publications support the research applications described above. References are provided for informational purposes to assist researchers in their literature review.
Total references: 4
Note: The information provided is for research reference only. It summarizes published in-vitro, animal and, where cited, human clinical studies of the compound; findings from those studies are not claims about this product. This product is intended for laboratory research purposes only. Not for human or veterinary use.
Common questions
- What purity is KPV, and how is it tested?
- KPV is supplied at 99%+ purity. Each production lot is tested by an independent third-party laboratory, with HPLC for purity and mass spectrometry for identity. Published certificates can be looked up by the lot number printed on your vial in our COA library.
- Does KPV come with a Certificate of Analysis?
- Certificates are published online rather than printed in the box. You can view and download the certificate on this page before you buy, and match the lot number on your vial to its certificate in the COA library. Our guide on how to read a peptide COA explains each section.
- How fast does KPV ship?
- Orders placed before 2 PM EST ship the same day from the United States, with tracking and discreet packaging.
- How should KPV be stored?
- Store at -20°C. Our storage and handling guide covers temperature, light and moisture in more detail.
- What if independent testing doesn't confirm the stated purity?
- Our Purity Guarantee covers it: if independent testing does not confirm the stated purity, you get a full refund and a free replacement.
- Is KPV for human use?
- No. KPV is sold strictly for laboratory research use only. It is not for human or veterinary use, and we do not provide dosing or administration guidance.
Research Use Only: This product is intended for laboratory research purposes only. Not for human or veterinary use. By purchasing, you confirm that you are a qualified researcher and will use this product in accordance with all applicable regulations.