Certificate of Analysis
Each batch of TZ-2 undergoes rigorous third-party testing to ensure purity and identity verification. The lab report for the latest batch is being finalized.
TZ-2 Dual Incretin Agonist
99%+ purity, independently tested
Ships same day when ordered before 2 PM EST · tracked and discreet
TZ-2 is a synthetic 39-amino acid peptide that functions as a dual agonist at both GLP-1 and GIP receptors. This innovative dual incretin approach activates two complementary metabolic pathways, making it a powerful research tool for studying glucose homeostasis, appetite regulation, and energy metabolism in laboratory settings.
99%+
20mg
Bundle & Save
Order before 2 PM EST, ships the same day. Fast, fully tracked, and sent in discreet, secure packaging. Free shipping on orders over $99.
Purity Guarantee. If independent third-party testing doesn't confirm our stated purity standards, you get a full refund plus a free replacement.
For Research Use Only
Intended for in-vitro research only. Not for human consumption. Must be 21+.
Specifications
Certificate of Analysis
Each batch of TZ-2 undergoes rigorous third-party testing to ensure purity and identity verification. The lab report for the latest batch is being finalized.
Research background
TZ-2 (Tirzepatide-Type) Dual GIP/GLP-1 Agonist: A Research Overview
The receptor biology behind tirzepatide-type dual GIP and GLP-1 receptor agonism, what 'imbalanced and biased' agonism means, what the SURPASS and SURMOUNT trials reported, and how dual agonism differs from triple.
Overview
Biochemical Characteristics
TZ-2 incorporates structural elements from both GIP and GLP-1, enabling high-affinity binding to both receptors. Published pharmacology describes this dual agonism as imbalanced, with greater potency at GIPR than at GLP-1R, and biased signalling at GLP-1R.
Research Applications
Pathway / Mechanistic Context
Preclinical Research Summary
Form & Analytical Testing
Mechanisms of Action
Dual Receptor Activation - Simultaneous agonism at GLP-1R and GIPR, with greater relative potency at GIPR in published studies
Glucose-Dependent Insulin Secretion - Potentiates β-cell insulin release only under hyperglycemic conditions
Appetite Regulation - Activates satiety centers through hypothalamic GLP-1R signaling
Gastric Emptying - Delays gastric transit to prolong nutrient absorption and reduce postprandial glucose
Research Applications
1Metabolic Research
Studies on glucose metabolism and insulin secretion through dual incretin pathway activation.
Key Research Findings
- Greater glycemic control than a selective GLP-1R agonist in a published head-to-head trial
- Enhanced insulin secretion in glucose-dependent manner
- Reduces glucagon secretion during hyperglycemia
- Improved β-cell function and insulin sensitivity in published studies
2Appetite & Energy Balance Research
Investigation of food intake regulation and body weight effects.
Key Research Findings
- Activates hypothalamic satiety pathways through GLP-1R
- Reduces food intake in animal models
- Greater body-weight reduction than a GLP-1R agonist alone in published studies
- GIPR component may enhance metabolic efficiency
3Dual Incretin Pharmacology
Studies on combined receptor activation and pathway synergy.
Key Research Findings
- High-affinity GIPR agonism with lower relative GLP-1R potency (imbalanced agonism)
- Synergistic effects exceed single pathway activation in preclinical studies
- Useful for comparing mono- vs. dual-agonist approaches
- Novel target for metabolic disease research
Supporting Research & Bibliography
The following peer-reviewed publications support the research applications described above. References are provided for informational purposes to assist researchers in their literature review.
Total references: 4
Note: The information provided is for research reference only. It summarizes published in-vitro, animal and, where cited, human clinical studies of the compound; findings from those studies are not claims about this product. This product is intended for laboratory research purposes only. Not for human or veterinary use.
Common questions
- What purity is TZ-2, and how is it tested?
- TZ-2 is supplied at 99%+ purity. Each production lot is tested by an independent third-party laboratory, with HPLC for purity and mass spectrometry for identity. Published certificates can be looked up by the lot number printed on your vial in our COA library.
- Does TZ-2 come with a Certificate of Analysis?
- Certificates are published online rather than printed in the box. You can view and download the certificate on this page before you buy, and match the lot number on your vial to its certificate in the COA library. Our guide on how to read a peptide COA explains each section.
- How fast does TZ-2 ship?
- Orders placed before 2 PM EST ship the same day from the United States, with tracking and discreet packaging.
- How should TZ-2 be stored?
- Store at -20°C. Our storage and handling guide covers temperature, light and moisture in more detail.
- What if independent testing doesn't confirm the stated purity?
- Our Purity Guarantee covers it: if independent testing does not confirm the stated purity, you get a full refund and a free replacement.
- Is TZ-2 for human use?
- No. TZ-2 is sold strictly for laboratory research use only. It is not for human or veterinary use, and we do not provide dosing or administration guidance.
Research Use Only: This product is intended for laboratory research purposes only. Not for human or veterinary use. By purchasing, you confirm that you are a qualified researcher and will use this product in accordance with all applicable regulations.