Certificate of Analysis
Each batch of RT-3 undergoes rigorous third-party testing to ensure purity and identity verification. View the full lab report below.
RT-3 Triple Incretin Agonist
99%+ purity, independently tested · View COA
Ships same day when ordered before 2 PM EST · tracked and discreet
RT-3 is a synthetic peptide that functions as a triple agonist at GLP-1, GIP, and glucagon receptors. This advanced triple-receptor approach activates three complementary metabolic pathways, making it the most comprehensive research tool for studying glucose homeostasis, energy expenditure, appetite regulation, and lipid metabolism in laboratory settings.
99%+
10mg
Bundle & Save
Order before 2 PM EST, ships the same day. Fast, fully tracked, and sent in discreet, secure packaging. Free shipping on orders over $99.
Purity Guarantee. If independent third-party testing doesn't confirm our stated purity standards, you get a full refund plus a free replacement.
For Research Use Only
Intended for in-vitro research only. Not for human consumption. Must be 21+.
Specifications
Certificate of Analysis
Each batch of RT-3 undergoes rigorous third-party testing to ensure purity and identity verification. View the full lab report below.
Research background
What Is RT-3? The Retatrutide-Type Triple Agonist, Explained for Researchers
How retatrutide-type triple agonism at the GLP-1, GIP and glucagon receptors was designed, what the published rodent and phase 2 literature reports, and which questions remain open for laboratory study.
Buy it as a stack
This compound is part of our curated sets. Same vials, same testing, lower total.
Overview
Biochemical Characteristics
RT-3 incorporates structural elements enabling activity at all three target receptors: GLP-1R, GIPR, and glucagon receptor. Published pharmacology reports unequal potency across the three receptors, highest at GIPR and lower at GLP-1R and the glucagon receptor.
Research Applications
Pathway / Mechanistic Context
Preclinical Research Summary
Form & Analytical Testing
Mechanisms of Action
Triple Receptor Activation - Simultaneous agonism at GLP-1R, GIPR, and glucagon receptor (GCGR)
Enhanced Energy Expenditure - Glucagon receptor activation promotes thermogenesis, fat oxidation, and energy expenditure
Glucose-Dependent Insulin Secretion - GLP-1R and GIPR components support glucose homeostasis in a glucose-dependent manner
Hepatic Metabolism - Glucagon receptor activation promotes hepatic lipid oxidation and reduces liver fat
Research Applications
1Advanced Metabolic Research
Studies on glucose and lipid metabolism through triple receptor pathway activation.
Key Research Findings
- Studied for metabolic effects beyond those of dual-pathway agonists
- Glucagon receptor component enhances energy expenditure in rodent studies
- Maintains glucose homeostasis through incretin balance in preclinical models
- Improved hepatic lipid metabolism through glucagon signaling in preclinical models
2Energy Expenditure & Thermogenesis
Investigation of glucagon-mediated metabolic rate effects.
Key Research Findings
- Increases energy expenditure through GCGR activation in rodent models
- Promotes thermogenesis and fat oxidation in rodent models
- Greater body-weight reduction than incretin-only agonism in rodent studies
- Balanced by glucose-protective incretin actions
3Hepatic Lipid Research
Studies on liver fat metabolism and hepatic function.
Key Research Findings
- Reduces hepatic lipid content in preclinical models
- Promotes hepatic fatty acid oxidation
- Decreases liver triglyceride synthesis
- Potential for hepatic steatosis research models
Supporting Research & Bibliography
The following peer-reviewed publications support the research applications described above. References are provided for informational purposes to assist researchers in their literature review.
Total references: 4
Note: The information provided is for research reference only. It summarizes published in-vitro, animal and, where cited, human clinical studies of the compound; findings from those studies are not claims about this product. This product is intended for laboratory research purposes only. Not for human or veterinary use.
Common questions
- What purity is RT-3, and how is it tested?
- RT-3 is supplied at 99%+ purity. Each production lot is tested by an independent third-party laboratory, with HPLC for purity and mass spectrometry for identity. Published certificates can be looked up by the lot number printed on your vial in our COA library.
- Does RT-3 come with a Certificate of Analysis?
- Certificates are published online rather than printed in the box. You can view and download the certificate on this page before you buy, and match the lot number on your vial to its certificate in the COA library. Our guide on how to read a peptide COA explains each section.
- How fast does RT-3 ship?
- Orders placed before 2 PM EST ship the same day from the United States, with tracking and discreet packaging.
- How should RT-3 be stored?
- Store at -20°C. Our storage and handling guide covers temperature, light and moisture in more detail.
- What if independent testing doesn't confirm the stated purity?
- Our Purity Guarantee covers it: if independent testing does not confirm the stated purity, you get a full refund and a free replacement.
- Is RT-3 for human use?
- No. RT-3 is sold strictly for laboratory research use only. It is not for human or veterinary use, and we do not provide dosing or administration guidance.
Research Use Only: This product is intended for laboratory research purposes only. Not for human or veterinary use. By purchasing, you confirm that you are a qualified researcher and will use this product in accordance with all applicable regulations.